MolNFT v1 · #99893 · protein

Crystal structure of a nucleoporin

4MHC · Nucleoporin NUP157: “Crystal structure of a nucleoporin”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #99893 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4MHC
Type: protein
Length: 671 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP157
UniProt: P40064
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP157	protein	671	32% helix, 29% strand	P40064

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1080	0.78	0.80	75	empty
2	51	0.70	0.98	18	empty
3	105	0.61	0.87	19	empty
4	204	0.58	0.80	28	empty
5	112	0.40	0.75	15	empty

Compared structures

4MHC · Crystal Structure of a Nucleoporin · the same entry in another collection · chain A against A, TM-score 1.00
P40064 · AlphaFold monomer V2.0 prediction for nucleoporin NUP157 (P40064) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40064
Elsewhere: RCSB PDB 4MHC · PDBe 4MHC · UniProt P40064

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