MolNFT v1 · #99818 · protein
Structure of the core fragment of human PR70
4MEW · SERINE/THREONINE-protein phosphatase 2A regulatory subunit…: “Structure of the core fragment of human PR70”. X-ray diffraction, 1 ligand (CA), 5 pockets (best druggability 0.45). MolNFT v1 #99818 on GenesisL1: 3D structure, binding…
- PDB
- 4MEW
- Type
- protein
- Length
- 348 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A regulatory subunit B'' subunit beta
- UniProt
- Q9Y5P8
- Ligands
- CA
- Pockets
- 5 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A regulatory subunit B'' subunit beta | protein | 348 | 61% helix, 5% strand | Q9Y5P8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.45 | 0.77 | 29 | empty |
| 2 | 106 | 0.35 | 0.73 | 17 | empty |
| 3 | 61 | 0.32 | 0.76 | 19 | empty |
| 4 | 60 | 0.31 | 0.75 | 18 | empty |
| 5 | 51 | 0.25 | 0.73 | 17 | empty |
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y5P8
- Elsewhere: RCSB PDB 4MEW · PDBe 4MEW · UniProt Q9Y5P8
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