MolNFT v1 · #99648 · protein

Crystal structure of the human filamin a ig-like domains 3-5

4M9P · Filamin-a: “Crystal structure of the human filamin a ig-like domains 3-5”. X-ray diffraction, 3 pockets (best druggability 0.42). MolNFT v1 #99648 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4M9P
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Filamin-a
UniProt: P21333
Pockets: 3 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Filamin-a	protein	289	5% helix, 49% strand	P21333

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.42	0.77	22	empty
2	71	0.34	0.76	22	empty
3	69	0.29	0.73	22	empty

Compared structures

4M9P · Crystal structure of the human filamin A Ig-like domains 3-5 · the same entry in another collection · chain A against A, TM-score 1.00
P21333 · AlphaFold monomer V2.0 prediction for filamin-a (P21333) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21333
Elsewhere: RCSB PDB 4M9P · PDBe 4M9P · UniProt P21333

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