MolNFT v1 · #99567 · protein
Crystal structure of LSM2-8 complex, space group P21
4M78 · U6 snrna-associated sm-like protein LSM8: “Crystal structure of LSM2-8 complex, space group P21”. X-ray diffraction, 10 pockets (best druggability 0.59). MolNFT v1 #99567 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4M78
- Type
- protein
- Length
- 1,028 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U6 snrna-associated sm-like protein LSM8; U6 snrna-associated sm-like protein LSM2; U6…
- UniProt
- P47093, P38203, P57743, Q06406, P40089, P53905, P40070
- Pockets
- 10 · best druggability 0.59
Structure
x-ray diffraction · 11 distinct chains · 15% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, H | U6 snrna-associated sm-like protein LSM8 | protein | 67 | 10% helix, 55% strand | P47093 |
| B | U6 snrna-associated sm-like protein LSM2 | protein | 87 | 26% helix, 36% strand | P38203 |
| C, J | U6 snrna-associated sm-like protein LSM3 | protein | 77 | 10% helix, 60% strand | P57743 |
| D | U6 snrna-associated sm-like protein LSM6 | protein | 75 | 15% helix, 51% strand | Q06406 |
| E | U6 snrna-associated sm-like protein LSM5 | protein | 73 | 14% helix, 55% strand | P40089 |
| F, M | U6 snrna-associated sm-like protein LSM7 | protein | 65 | 6% helix, 58% strand | P53905 |
| G | U6 snrna-associated sm-like protein LSM4 | protein | 70 | 13% helix, 51% strand | P40070 |
| I | U6 snrna-associated sm-like protein LSM2 | protein | 85 | 21% helix, 38% strand | P38203 |
| K | U6 snrna-associated sm-like protein LSM6 | protein | 74 | 14% helix, 54% strand | Q06406 |
| L | U6 snrna-associated sm-like protein LSM5 | protein | 75 | 15% helix, 55% strand | P40089 |
| N | U6 snrna-associated sm-like protein LSM4 | protein | 71 | 13% helix, 51% strand | P40070 |
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.59 | 0.82 | 21 | empty |
| 2 | 56 | 0.46 | 0.84 | 16 | empty |
| 3 | 55 | 0.44 | 0.84 | 16 | empty |
| 4 | 80 | 0.42 | 0.79 | 20 | empty |
| 5 | 53 | 0.39 | 0.80 | 14 | empty |
Interfaces
18 interfaces between chains.
- B–C · 1293 Ų buried · 19 hydrogen bonds · protein-protein
- I–J · 1272 Ų buried · 20 hydrogen bonds · protein-protein
- H–I · 1017 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 976 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 931 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4M78 · Crystal structure of Lsm2-8 complex, space group P21 · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47093
- Every structure of UniProt P38203
- Every structure of UniProt P57743
- Every structure of UniProt Q06406
- Every structure of UniProt P40089
- Every structure of UniProt P53905
- Every structure of UniProt P40070
- Elsewhere: RCSB PDB 4M78 · PDBe 4M78 · UniProt P47093 · UniProt P38203 · UniProt P57743 · UniProt Q06406 · UniProt P40089 · UniProt P53905 · UniProt P40070
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.