MolNFT v1 · #99522 · protein

Crystal structure of the USP7/HAUSP catalytic domain

4M5X · Ubiquitin carboxyl-terminal hydrolase 7: “Crystal structure of the USP7/HAUSP catalytic domain”. X-ray diffraction, 1 ligand (BR), 10 pockets (best druggability 0.56). MolNFT v1 #99522 on GenesisL1: 3D structure, binding sites and…

PDB: 4M5X
Type: protein
Length: 676 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin carboxyl-terminal hydrolase 7
EC: 3.4.19.12
UniProt: Q93009
Ligands: BR
Pockets: 10 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12)	protein	339	32% helix, 27% strand	Q93009
B	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12)	protein	337	33% helix, 27% strand	Q93009

Ligands and binding sites

BR · Bromide ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	246	0.56	0.78	36	empty
2	228	0.56	0.78	34	empty
3	121	0.45	0.78	20	BR
4	107	0.45	0.78	23	BR
5	83	0.35	0.75	17	empty

Compared structures

4M5X · Crystal structure of the USP7/HAUSP catalytic domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93009
Elsewhere: RCSB PDB 4M5X · PDBe 4M5X · UniProt Q93009

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