MolNFT v1 · #99222 · protein
Crystal structure of MYO5A globular tail domain in complex with melanophilin gtbd
4LX2 · Unconventional myosin-va: “Crystal structure of MYO5A globular tail domain in complex with melanophilin gtbd”. X-ray diffraction. MolNFT v1 #99222 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4LX2
- Type
- protein
- Length
- 373 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-va; Melanophilin
- UniProt
- Q9Y4I1, Q91V27
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-va | protein | 361 | 63% helix, 2% strand | Q9Y4I1 |
| B | Melanophilin | protein | 12 | 25% helix, 17% strand | Q91V27 |
Ligands and binding sites
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 708 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4LX2 · Crystal structure of Myo5a globular tail domain in complex with melanophilin GTBD · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y4I1 · AlphaFold monomer V2.0 prediction for unconventional myosin-va (Q9Y4I1) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q91V27 · AlphaFold monomer V2.0 prediction for melanophilin (Q91V27) · a predicted model of the same protein · chain B against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y4I1
- Every structure of UniProt Q91V27
- Elsewhere: RCSB PDB 4LX2 · PDBe 4LX2 · UniProt Q9Y4I1 · UniProt Q91V27
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.