Crystal structure of MYO5A globular tail domain in complex with melanophilin gtbd

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 3% strand (DSSP).

Ligands and binding sites

• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 708 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 4LX2 · Crystal structure of Myo5a globular tail domain in complex with melanophilin GTBD · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y4I1 · AlphaFold monomer V2.0 prediction for unconventional myosin-va (Q9Y4I1) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q91V27 · AlphaFold monomer V2.0 prediction for melanophilin (Q91V27) · a predicted model of the same protein · chain B against A, TM-score 0.42

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y4I1
• Every structure of UniProt Q91V27
• Elsewhere: RCSB PDB 4LX2 · PDBe 4LX2 · UniProt Q9Y4I1 · UniProt Q91V27