MolNFT v1 · #99210 · protein
Crystal structure of PRMT6-sah
4LWP · Arginine N-methyltransferase, putative: “Crystal structure of PRMT6-sah”. X-ray diffraction, 2 ligands (SAH, IOD), 4 pockets (best druggability 0.60). MolNFT v1 #99210 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4LWP
- Type
- protein
- Length
- 683 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginine N-methyltransferase, putative
- UniProt
- Q57U70
- Ligands
- SAH, IOD
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Arginine N-methyltransferase, putative | protein | 342 | 36% helix, 29% strand | Q57U70 |
| A | Arginine N-methyltransferase, putative | protein | 341 | 36% helix, 29% strand | Q57U70 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains B, A
- IOD · Iodide ion · ion · 9 copies · chains B, A
- PGE · Triethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 242 | 0.60 | 0.80 | 36 | SAH |
| 2 | 285 | 0.57 | 0.77 | 38 | IOD, SAH |
| 3 | 128 | 0.39 | 0.74 | 20 | PGE |
| 4 | 75 | 0.33 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- B–A · 1633 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4LWP · Crystal structure of PRMT6-SAH · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q57U70
- Elsewhere: RCSB PDB 4LWP · PDBe 4LWP · UniProt Q57U70
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