Complex of ovine serum albumin with 3,5-diiodosalicylic acid

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).

Ligands and binding sites

• DIU · 2-hydroxy-3,5-diiodo-benzoic acid · ligand · 2 copies · chains A
• LMR · (2S)-2-hydroxybutanedioic acid · ligand · 2 copies · chains A
• 2Q5 · (2R)-2-{[(2R)-2-{[(2S)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propyl]oxy}propan-1-ol · ligand · 2 copies · chains A
• SIN · Succinic acid · additive · 3 copies · chains A
• ACT · Acetate ion · additive · 3 copies · chains A
• MLI · Malonate ion · additive · 2 copies · chains A
• FMT · Formic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

• 4LUH · Complex of ovine serum albumin with 3,5-diiodosalicylic acid · the same entry in another collection · chain A against A, TM-score 1.00
• P14639 · AlphaFold monomer V2.0 prediction for albumin (P14639) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P14639
• Elsewhere: RCSB PDB 4LUH · PDBe 4LUH · UniProt P14639