MolNFT v1 · #98994 · protein
The crystal structures of the brucella protein tcpb and the tlr adaptor protein tirap show structural differences in microbial tir mimicry.
4LQC: “The crystal structures of the brucella protein tcpb and the tlr adaptor protein tirap show structural…”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #98994 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4LQC
- Type
- protein
- Length
- 261 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tcpb
- UniProt
- Q8YF53
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tcpb | protein | 129 | 44% helix, 18% strand | Q8YF53 |
| B | Tcpb | protein | 132 | 45% helix, 22% strand | Q8YF53 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.43 | 0.79 | 27 | empty |
| 2 | 62 | 0.37 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 664 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4LQC · The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YF53
- Elsewhere: RCSB PDB 4LQC · PDBe 4LQC · UniProt Q8YF53
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