Research workbench
The crystal structures of the brucella protein tcpb and the tlr adaptor protein tirap show structural differences in microbial tir mimicry.
Analyse The crystal structures of the brucella protein tcpb and the tlr adaptor protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LQC
- Type
- protein
- Length
- 261 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tcpb
- UniProt
- Q8YF53
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tcpb | protein | 129 | 44% helix, 18% strand | Q8YF53 |
| B | Tcpb | protein | 132 | 45% helix, 22% strand | Q8YF53 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.43 | 0.79 | 27 | empty |
| 2 | 62 | 0.37 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 664 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4LQC · The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YF53
- Elsewhere: RCSB PDB 4LQC · PDBe 4LQC · UniProt Q8YF53
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