MolNFT v1 · #98935 · protein
The crystal structure of the orphan nuclear receptor pnr ligand binding domain fused with mbp
4LOG · Maltose ABC transporter periplasmic protein and NR2E3…: “The crystal structure of the orphan nuclear receptor pnr ligand binding domain fused with mbp”. X-ray diffraction, 17 pockets (best druggability 0.74). MolNFT v1 #98935 on…
- PDB
- 4LOG
- Type
- protein
- Length
- 785 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct
- UniProt
- K0BGG6, Q8IVZ9
- Pockets
- 17 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct | protein | 553 | 51% helix, 12% strand | K0BGG6, Q8IVZ9 |
| B | Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct | protein | 232 | 62% helix, 1% strand | K0BGG6, Q8IVZ9 |
Pockets
17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 625 | 0.74 | 0.81 | 59 | empty |
| 2 | 302 | 0.70 | 0.84 | 31 | empty |
| 3 | 414 | 0.69 | 0.81 | 47 | empty |
| 4 | 60 | 0.67 | 0.95 | 23 | empty |
| 5 | 308 | 0.58 | 0.77 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1177 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4LOG · The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K0BGG6
- Every structure of UniProt Q8IVZ9
- Elsewhere: RCSB PDB 4LOG · PDBe 4LOG · UniProt K0BGG6 · UniProt Q8IVZ9
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