Research workbench
The crystal structure of the orphan nuclear receptor pnr ligand binding domain fused with mbp
Analyse The crystal structure of the orphan nuclear receptor pnr ligand binding domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LOG
- Type
- protein
- Length
- 785 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct
- UniProt
- K0BGG6, Q8IVZ9
- Pockets
- 17 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct | protein | 553 | 51% helix, 12% strand | K0BGG6, Q8IVZ9 |
| B | Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct | protein | 232 | 62% helix, 1% strand | K0BGG6, Q8IVZ9 |
Pockets
17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 625 | 0.74 | 0.81 | 59 | empty |
| 2 | 302 | 0.70 | 0.84 | 31 | empty |
| 3 | 414 | 0.69 | 0.81 | 47 | empty |
| 4 | 60 | 0.67 | 0.95 | 23 | empty |
| 5 | 308 | 0.58 | 0.77 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1177 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4LOG · The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K0BGG6
- Every structure of UniProt Q8IVZ9
- Elsewhere: RCSB PDB 4LOG · PDBe 4LOG · UniProt K0BGG6 · UniProt Q8IVZ9
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