MolNFT v1 · #98607 · protein

Human methyltransferase-like protein 21A

4LEC · Protein-lysine methyltransferase METTL21A: “Human methyltransferase-like protein 21A”. X-ray diffraction, 2 ligands (SAH, UNX), 3 pockets (best druggability 0.67). MolNFT v1 #98607 on GenesisL1: 3D structure, binding sites and…

PDB: 4LEC
Type: protein
Length: 403 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-lysine methyltransferase METTL21A
EC: 2.1.1.-
UniProt: Q8WXB1
Ligands: SAH, UNX
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-lysine methyltransferase METTL21A (EC 2.1.1.-)	protein	202	35% helix, 27% strand	Q8WXB1
B	Protein-lysine methyltransferase METTL21A (EC 2.1.1.-)	protein	201	37% helix, 27% strand	Q8WXB1

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B
UNX · Unknown atom or ion · ion · 11 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.67	0.87	36	SAH
2	191	0.65	0.85	31	UNX
3	154	0.64	0.86	31	SAH

Interfaces

1 interface between chains.

A–B · 487 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4LEC · Human Methyltransferase-Like Protein 21A · the same entry in another collection · chain B against B, TM-score 1.00
Q8WXB1 · AlphaFold monomer V2.0 prediction for protein N-lysine methyltransferase METTL21A (Q8WXB1) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WXB1
Elsewhere: RCSB PDB 4LEC · PDBe 4LEC · UniProt Q8WXB1

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