MolNFT v1 · #98467 · protein
Crystal structure of the UBE2G2:RING-G2BR complex
4LAD · Ubiquitin-conjugating enzyme E2 G2: “Crystal structure of the UBE2G2:RING-G2BR complex”. X-ray diffraction, 2 ligands (OXL, ZN), 2 pockets (best druggability 0.36). MolNFT v1 #98467 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4LAD
- Type
- protein
- Length
- 223 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 G2; E3 ubiquitin-protein ligase amfr
- EC
- 6.3.2.19, 6.3.2.-
- UniProt
- P60604, Q9UKV5
- Ligands
- OXL, ZN
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2 G2 (EC 6.3.2.19) | protein | 154 | 35% helix, 17% strand | P60604 |
| B | E3 ubiquitin-protein ligase amfr (EC 6.3.2.-) | protein | 69 | 45% helix, 9% strand | Q9UKV5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.36 | 0.74 | 19 | empty |
| 2 | 86 | 0.34 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1226 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4LAD · Crystal Structure of the Ube2g2:RING-G2BR complex · the same entry in another collection · chain A against A, TM-score 1.00
- P60604 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 G2 (P60604) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9UKV5 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase amfr (Q9UKV5) · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60604
- Every structure of UniProt Q9UKV5
- Elsewhere: RCSB PDB 4LAD · PDBe 4LAD · UniProt P60604 · UniProt Q9UKV5
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