MolNFT v1 · #98425 · protein
Structure of the complex between the F360L ppargamma mutant and the ligand LT175 (space group I222)
4L96 · Peroxisome proliferator-activated receptor gamma: “Structure of the complex between the F360L ppargamma mutant and the ligand LT175 (space group I222)”. X-ray diffraction, 1 ligand (LRG), 1 pocket (best druggability 0.79). MolNFT v1…
- PDB
- 4L96
- Type
- protein
- Length
- 260 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxisome proliferator-activated receptor gamma
- UniProt
- P37231
- Ligands
- LRG
- Pockets
- 1 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 70% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxisome proliferator-activated receptor gamma | protein | 260 | 70% helix, 5% strand | P37231 |
Ligands and binding sites
- LRG · (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 719 | 0.79 | 0.83 | 59 | LRG |
Compared structures
- 4L96 · Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37231
- Elsewhere: RCSB PDB 4L96 · PDBe 4L96 · UniProt P37231
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