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Ligand · LRG

LRG · (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid

LRG, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (C21 H18 O3, 318.4 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
LRG
Formula
C21 H18 O3
Class
ligand
Structures
9
PDB entries
5

Binding sites

LRG in 9 structures; the first of them:

  • 3B3K · Crystal structure of the complex between PPARgamma and the full agonist LT175 · LRG A1 · binds PHE282, GLN283, CYS285, GLN286, SER289, HIS323, ILE326, TYR327 and 12 more
  • 3D6D · Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer) · LRG A1 · binds PHE264, ILE281, GLY284, CYS285, ARG288, SER289, ILE326, TYR327 and 8 more
  • 4L96 · Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space… · LRG A501 · binds PHE282, GLN283, CYS285, GLN286, ARG288, SER289, HIS323, ILE326 and 11 more
  • 4L98 · Crystal structure of the complex of F360L PPARgamma mutant with the ligand LT175 · LRG A501 · binds PHE282, GLN283, CYS285, GLN286, ARG288, SER289, HIS323, ILE326 and 13 more
  • 8HHP · Crystal structure of PPARg-LBD complexed with three partial agonists, one nTZDpa and two… · LRG A502 · binds PHE226, PRO227, LEU228, LYS232, ALA233, ILE236, ARG288, GLU291 and 5 more
  • 3B3K · Crystal structure of the complex between ppargamma and the full agonist LT175 · LRG A1 · binds PHE282, GLN283, CYS285, GLN286, SER289, HIS323, ILE326, TYR327 and 12 more
  • 3D6D · Crystal structure of the complex between ppargamma lbd and the LT175(R-enantiomer) · LRG A1 · binds PHE264, ILE281, GLY284, CYS285, ARG288, SER289, ILE326, TYR327 and 8 more
  • 4L96 · Structure of the complex between the F360L ppargamma mutant and the ligand LT175 (space… · LRG A501 · binds PHE282, GLN283, CYS285, GLN286, ARG288, SER289, HIS323, ILE326 and 11 more
  • 4L98 · Crystal structure of the complex of F360L ppargamma mutant with the ligand LT175 · LRG A501 · binds PHE282, GLN283, CYS285, GLN286, ARG288, SER289, HIS323, ILE326 and 13 more

Residues it binds most

LEU 12, HIS 11, GLN 9, PHE 12, SER 11, TYR 11, ILE 12, MET 12, CYS 11, ARG 9 (residue and the binding sites it lines).

Found with

  • NZA · 5-chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid

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