MolNFT v1 · #98272 · protein
Crystal structure of mouse ryanodine receptor isoform 2 (RYR2) 1-547
4L4H · Ryanodine receptor 2: “Crystal structure of mouse ryanodine receptor isoform 2 (RYR2) 1-547”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.69). MolNFT v1 #98272 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4L4H
- Type
- protein
- Length
- 466 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 2
- UniProt
- E9Q401
- Ligands
- CL
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ryanodine receptor 2 | protein | 466 | 28% helix, 32% strand | E9Q401 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A
- PGE · Triethylene glycol · additive · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 352 | 0.69 | 0.82 | 47 | PGE |
| 2 | 534 | 0.66 | 0.77 | 66 | PEG |
Compared structures
- 4L4H · Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9Q401
- Elsewhere: RCSB PDB 4L4H · PDBe 4L4H · UniProt E9Q401
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