MolNFT v1 · #98095 · protein

Structure of PI3K gamma with imidazopyridine inhibitors

4KZ0 · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic…: “Structure of PI3K gamma with imidazopyridine inhibitors”. X-ray diffraction, 2 ligands (1UJ, SO4), 14 pockets (best druggability 0.82). MolNFT v1 #98095 on GenesisL1: 3D…

PDB: 4KZ0
Type: protein
Length: 833 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
EC: 2.7.1.153, 2.7.11.1
UniProt: P48736
Ligands: 1UJ, SO4
Pockets: 14 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153, 2.7.11.1)	protein	833	45% helix, 17% strand	P48736

Ligands and binding sites

1UJ · methyl 2-(acetylamino)-1,3-benzothiazole-6-carboxylate · ligand · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1004	0.82	0.83	74	SO4
2	113	0.79	0.97	34	empty
3	267	0.68	0.83	39	1UJ
4	386	0.64	0.78	47	empty
5	144	0.56	0.82	24	empty

Compared structures

4KZ0 · Structure of PI3K gamma with Imidazopyridine inhibitors · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48736
Elsewhere: RCSB PDB 4KZ0 · PDBe 4KZ0 · UniProt P48736

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.