MolNFT v1 · #98026 · protein

TRNA guanine transglycosylase (tgt) in complex with furanoside-based lin-benzoguanine 3

4KWO · Queuine tRNA-ribosyltransferase: “TRNA guanine transglycosylase (tgt) in complex with furanoside-based lin-benzoguanine 3”. X-ray diffraction, 2 ligands (1UD, ZN), 3 pockets (best druggability 0.64). MolNFT v1 #98026 on GenesisL1…

PDB: 4KWO
Type: protein
Length: 352 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: 1UD, ZN
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	352	46% helix, 16% strand	P28720

Ligands and binding sites

1UD · methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-3-O-methyl-beta-D-ribo-hexofuranoside · ligand · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	322	0.64	0.80	49	1UD
2	55	0.34	0.78	17	GOL
3	61	0.29	0.74	14	empty

Compared structures

4KWO · tRNA guanine transglycosylase (TGT) in complex with Furanoside-Based lin-Benzoguanine 3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 4KWO · PDBe 4KWO · UniProt P28720

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.