MolNFT v1 · #98016 · protein
GDP-bound, double-stranded, curved ftsz protofilament structure
4KWE · Cell division protein ftsz: “GDP-bound, double-stranded, curved ftsz protofilament structure”. X-ray diffraction, 1 ligand (GDP), 10 pockets (best druggability 0.55). MolNFT v1 #98016 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4KWE
- Type
- protein
- Length
- 895 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein ftsz
- UniProt
- P64170
- Ligands
- GDP
- Pockets
- 10 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division protein ftsz | protein | 305 | 44% helix, 24% strand | P64170 |
| B, C | Cell division protein ftsz | protein | 295 | 45% helix, 25% strand | P64170 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.55 | 0.77 | 42 | GDP |
| 2 | 159 | 0.50 | 0.78 | 30 | GDP |
| 3 | 132 | 0.45 | 0.77 | 29 | GDP |
| 4 | 129 | 0.40 | 0.74 | 24 | empty |
| 5 | 122 | 0.38 | 0.74 | 23 | empty |
Interfaces
2 interfaces between chains.
- B–C · 617 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 563 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4KWE · GDP-bound, double-stranded, curved FtsZ protofilament structure · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P64170
- Elsewhere: RCSB PDB 4KWE · PDBe 4KWE · UniProt P64170
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