MolNFT v1 · #97422 · protein
Crystal structure of P97/VCP N in complex with OTU1 ubxl
4KDL · Transitional endoplasmic reticulum ATPase: “Crystal structure of P97/VCP N in complex with OTU1 ubxl”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #97422 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4KDL
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transitional endoplasmic reticulum ATPase; Ubiquitin thioesterase OTU1
- EC
- 3.6.4.6, 3.4.19.12
- UniProt
- P55072, P43558
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transitional endoplasmic reticulum ATPase (EC 3.6.4.6) | protein | 174 | 17% helix, 37% strand | P55072 |
| B | Ubiquitin thioesterase OTU1 (EC 3.4.19.12) | protein | 69 | 19% helix, 42% strand | P43558 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.61 | 0.82 | 33 | empty |
| 2 | 52 | 0.26 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 636 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55072
- Every structure of UniProt P43558
- Elsewhere: RCSB PDB 4KDL · PDBe 4KDL · UniProt P55072 · UniProt P43558
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