UniProt P55072
Transitional endoplasmic reticulum ATPase (P55072)
Transitional endoplasmic reticulum ATPase (UniProt P55072), EC 3.6.4.6: 167 experimental structures on GenesisL1, 24 ligands bound, 981 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P55072
- Protein
- Transitional endoplasmic reticulum ATPase
- EC
- 3.6.4.6
- Experimental structures
- 167
- Predicted models
- 0
- Ligands
- 24
- Pockets
- 981 · 55 records with a druggable one
Structures
167 records of P55072 in the MolNFT archive: 167 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3EBB | PLAP/P97 complex | x-ray diffraction | E, F, G, H | — | — |
| 3EBB | PLAP/P97 complex | x-ray diffraction | E, F, G, H | — | — |
| 3HU1 | Structure of p97 N-D1 R95G mutant in complex with ATPgS | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HU1 | Structure of P97 N-D1 R95G mutant in complex with atpgs | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HU2 | Structure of p97 N-D1 R86A mutant in complex with ATPgS | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HU2 | Structure of P97 N-D1 R86A mutant in complex with atpgs | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HU3 | Structure of p97 N-D1 R155H mutant in complex with ATPgS | x-ray diffraction | A, B | — | — |
| 3HU3 | Structure of P97 N-D1 R155H mutant in complex with atpgs | x-ray diffraction | A, B | — | — |
| 3QC8 | Crystal Structure of FAF1 UBX Domain In Complex with p97/VCP N Domain Reveals The Conserved FcisP… | x-ray diffraction | A | — | — |
| 3QC8 | Crystal structure of FAF1 ubx domain in complex with P97/VCP N domain reveals the conserved fcisp… | x-ray diffraction | A | — | — |
| 3QQ7 | Crystal Structure of the p97 N-terminal domain | x-ray diffraction | A | — | — |
| 3QQ7 | Crystal structure of the P97 N-terminal domain | x-ray diffraction | A | — | — |
| 3QQ8 | Crystal structure of p97-N in complex with FAF1-UBX | x-ray diffraction | A | — | — |
| 3QQ8 | Crystal structure of P97-N in complex with FAF1-ubx | x-ray diffraction | A | — | — |
| 3QWZ | Crystal structure of FAF1 UBX-p97N-domain complex | x-ray diffraction | A | — | — |
| 3QWZ | Crystal structure of FAF1 ubx-P97N-domain complex | x-ray diffraction | A | — | — |
| 3TIW | Crystal structure of p97N in complex with the C-terminus of gp78 | x-ray diffraction | A, B | — | — |
| 3TIW | Crystal structure of P97N in complex with the C-terminus of GP78 | x-ray diffraction | A, B | — | — |
| 4KDI | Crystal structure of p97/VCP N in complex with OTU1 UBXL | x-ray diffraction | A, B | — | — |
| 4KDI | Crystal structure of P97/VCP N in complex with OTU1 ubxl | x-ray diffraction | A, B | — | — |
| 4KDL | Crystal structure of p97/VCP N in complex with OTU1 UBXL | x-ray diffraction | A | — | — |
| 4KDL | Crystal structure of P97/VCP N in complex with OTU1 ubxl | x-ray diffraction | A | — | — |
| 4KLN | Structure of p97 N-D1 A232E mutant in complex with ATPgS | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4KLN | Structure of P97 N-D1 A232E mutant in complex with atpgs | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4KO8 | Structure of p97 N-D1 R155H mutant in complex with ATPgS | x-ray diffraction | A, B | — | — |
| 4KO8 | Structure of P97 N-D1 R155H mutant in complex with atpgs | x-ray diffraction | A, B | — | — |
| 4KOD | Structure of p97 N-D1 R155H mutant in complex with ADP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4KOD | Structure of P97 N-D1 R155H mutant in complex with ADP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4P0A | Crystal structure of HOIP PUB domain in complex with p97 PIM | x-ray diffraction | B, D | — | — |
| 4P0A | Crystal structure of hoip pub domain in complex with P97 pim | x-ray diffraction | B, D | — | — |
| 5B6C | Structural Details of Ufd1 binding to p97 | x-ray diffraction | A | — | — |
| 5B6C | Structural details of UFD1 binding to P97 | x-ray diffraction | A | — | — |
| 5C18 | p97-delta709-728 in complex with ATP-gamma-S | x-ray diffraction | A, B, C, D, E, F | AGS, MG, CL | 20 (best 0.86) |
| 5C18 | P97-DELTA709-728 in complex with ATP-gamma-S | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5C19 | p97 variant 2 in the apo state | x-ray diffraction | A, B, C, D, E, F | SO4 | 20 (best 0.85) |
| 5C19 | P97 variant 2 in the apo state | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5C1B | P97-DELTA709-728 in complex with a UFD1-shp peptide | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5DYG | Structure of p97 N-D1 L198W mutant in complex with ADP | x-ray diffraction | A | ADP | 6 (best 0.68) |
| 5DYG | Structure of P97 N-D1 L198W mutant in complex with ADP | x-ray diffraction | A | — | — |
| 5DYI | Structure of p97 N-D1 wild-type in complex with ADP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | ADP | — |
| 5DYI | Structure of P97 N-D1 wild-type in complex with ADP | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 5EPP | Structural Insights into the Interaction of p97 N-terminus Domain and VBM Motif in Rhomboid… | x-ray diffraction | A | — | — |
| 5EPP | Structural insights into the interaction of P97 N-terminus domain and vbm motif in rhomboid… | x-ray diffraction | A | — | — |
| 5FTJ | Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor | electron microscopy | A, B, C, D, E, F | ADP, OJA | 20 (best 0.85) |
| 5FTJ | Cryo-EM structure of human P97 bound to UPCDC30245 inhibitor | electron microscopy | A, B, C, D, E, F | — | — |
| 5FTK | Cryo-EM structure of human p97 bound to ADP | electron microscopy | A, B, C, D, E, F | ADP | 20 (best 0.85) |
| 5FTK | Cryo-EM structure of human P97 bound to ADP | electron microscopy | A, B, C, D, E, F | — | — |
| 5FTL | Cryo-EM structure of human p97 bound to ATPgS (Conformation I) | electron microscopy | A, B, C, D, E, F | ADP | 20 (best 0.84) |
| 5FTL | Cryo-EM structure of human P97 bound to atpgs (conformation I) | electron microscopy | A, B, C, D, E, F | — | — |
| 5FTM | Cryo-EM structure of human p97 bound to ATPgS (Conformation II) | electron microscopy | A, B, C, D, E, F | AGS, ADP, MG | — |
| 5FTM | Cryo-EM structure of human P97 bound to atpgs (conformation II) | electron microscopy | A, B, C, D, E, F | — | — |
| 5FTN | Cryo-EM structure of human p97 bound to ATPgS (Conformation III) | electron microscopy | A, B, C, D, E, F | AGS, MG | — |
| 5FTN | Cryo-EM structure of human P97 bound to atpgs (conformation III) | electron microscopy | A, B, C, D, E, F | — | — |
| 5GLF | Structural insights into the interaction of p97 N-terminal domain and SHP motif in Derlin-1… | x-ray diffraction | A, C, E, G | — | — |
| 5GLF | Structural insights into the interaction of P97 N-terminal domain and shp motif in derlin-1… | x-ray diffraction | A, C, E, G | — | — |
| 5IFS | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that… | x-ray diffraction | B, D | ADP, MG, SO4 | 19 (best 0.77) |
| 5IFS | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in aspl that… | x-ray diffraction | B, D | — | — |
| 5IFW | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that… | x-ray diffraction | B | ADP | 14 (best 0.72) |
| 5IFW | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in aspl that… | x-ray diffraction | B | — | — |
| 5KIW | p97 ND1-L198W in complex with VIMP | x-ray diffraction | A, B | ANP, MG | 13 (best 0.64) |
107 records more on the page itself.
Ligands
- ADP · Adenosine-5'-diphosphate · in 76 records
- MG · Magnesium ion · in 44 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 22 records
- ATP · Adenosine-5'-triphosphate · in 19 records
- NA · Sodium ion · in 9 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 7 records
- JDP · 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide · in 5 records
- Y6Y · 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine · in 4 records
- A1AC1 · (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide · in 2 records
- AWD · ~{N}-(4-fluorophenyl)-4-methyl-piperazine-1-carboxamide · in 2 records
- BEF · Beryllium trifluoride ion · in 2 records
- EJW · (3-phenyl-1,2-oxazol-5-yl)methylazanium · in 2 records
- ELN · ~{N}-(4-chlorophenyl)-2-cyano-ethanamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- 6LY · (1S)-2-amino-1-(4-bromophenyl)ethan-1-ol · in 1 record
- CL · Chloride ion · in 1 record
- EJQ · ~{N}-(4-fluorophenyl)-2-pyrrolidin-1-yl-ethanamide · in 1 record
- ELQ · [3,4-bis(fluoranyl)phenyl]-(4-methylpiperazin-1-yl)methanone · in 1 record
- K · Potassium ion · in 1 record
- OJA · 1-(3-(5-fluoro-1H-indol-2-yl)phenyl)piperidin-4-yl)(2-(4-isopropyl-piperazin1-yl)ethyl)-carbamate · in 1 record
- PO4 · Phosphate ion · in 1 record
- SAH · S-adenosyl-L-homocysteine · in 1 record
- XNU · N-[3-(2,5-difluoro-4-{[(4M)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide · in 1 record
- XO8 · 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one · in 1 record
Elsewhere
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