MolNFT v1 · #9706 · protein

Crystal structure of RNase III endonuclease domain from aquifex aeolicus at 2.15 ångström resolution

1I4S · Ribonuclease III: “Crystal structure of RNase III endonuclease domain from aquifex aeolicus at 2.15 ångström resolution”. X-ray diffraction, 1 pocket (best druggability 0.29). MolNFT v1 #9706 on GenesisL1: 3D structure, binding…

PDB: 1I4S
Type: protein
Length: 294 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease III
EC: 3.1.26.3
UniProt: O67082
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ribonuclease III (EC 3.1.26.3)	protein	147	68% helix, 1% strand	O67082

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.29	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 1158 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

1I4S · Crystal structure of RNase III endonuclease domain from aquifex aeolicus at 2.15 ångström… · the same entry in another collection · chain B against B, TM-score 1.00
O67082 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (O67082) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O67082
Elsewhere: RCSB PDB 1I4S · PDBe 1I4S · UniProt O67082

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