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Crystal structure of RNase III endonuclease domain from aquifex aeolicus at 2.15 ångström resolution

Analyse Crystal structure of RNase III endonuclease domain from aquifex aeolicus at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I4S
Type: protein
Length: 294 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease III
EC: 3.1.26.3
UniProt: O67082
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ribonuclease III (EC 3.1.26.3)	protein	147	68% helix, 1% strand	O67082

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.29	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 1158 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

1I4S · Crystal structure of RNase III endonuclease domain from aquifex aeolicus at 2.15 ångström… · the same entry in another collection · chain B against B, TM-score 1.00
O67082 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (O67082) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O67082
Elsewhere: RCSB PDB 1I4S · PDBe 1I4S · UniProt O67082

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