MolNFT v1 · #96975 · protein
Crystal structure of human CLIC1 C24D mutant
4JZQ · Chloride intracellular channel protein 1: “Crystal structure of human CLIC1 C24D mutant”. X-ray diffraction, 2 pockets (best druggability 0.76). MolNFT v1 #96975 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4JZQ
- Type
- protein
- Length
- 471 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 1
- UniProt
- O00299
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride intracellular channel protein 1 | protein | 237 | 47% helix, 9% strand | O00299 |
| B | Chloride intracellular channel protein 1 | protein | 234 | 50% helix, 9% strand | O00299 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 444 | 0.76 | 0.85 | 47 | empty |
| 2 | 52 | 0.25 | 0.72 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 903 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00299
- Elsewhere: RCSB PDB 4JZQ · PDBe 4JZQ · UniProt O00299
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