MolNFT v1 · #96961 · protein

Crystal structure of a legionella phosphoinositide phosphatase: insights into lipid metabolism in pathogen host interaction

4JZA · Uncharacterized protein: “Crystal structure of a legionella phosphoinositide phosphatase: insights into lipid metabolism in pathogen…”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #96961 on GenesisL1: 3D…

PDB: 4JZA
Type: protein
Length: 1,632 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein
EC: 3.1.3.64
UniProt: D3HMN4
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein (EC 3.1.3.64)	protein	817	55% helix, 7% strand	D3HMN4
B	Uncharacterized protein (EC 3.1.3.64)	protein	815	54% helix, 7% strand	D3HMN4

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	544	0.79	0.85	54	empty
2	592	0.78	0.84	58	empty
3	1042	0.77	0.79	98	empty
4	617	0.76	0.82	65	empty
5	333	0.55	0.75	41	empty

Interfaces

1 interface between chains.

A–B · 2212 Å² buried · 41 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 21 modified (engineered).

Compared structures

4JZA · Crystal structure of a Legionella phosphoinositide phosphatase: insights into lipid… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D3HMN4
Elsewhere: RCSB PDB 4JZA · PDBe 4JZA · UniProt D3HMN4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.