Research workbench
Crystal structure of a legionella phosphoinositide phosphatase: insights into lipid metabolism in pathogen host interaction
Analyse Crystal structure of a legionella phosphoinositide phosphatase: insights into… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JZA
- Type
- protein
- Length
- 1,632 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- EC
- 3.1.3.64
- UniProt
- D3HMN4
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein (EC 3.1.3.64) | protein | 817 | 55% helix, 7% strand | D3HMN4 |
| B | Uncharacterized protein (EC 3.1.3.64) | protein | 815 | 54% helix, 7% strand | D3HMN4 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 544 | 0.79 | 0.85 | 54 | empty |
| 2 | 592 | 0.78 | 0.84 | 58 | empty |
| 3 | 1042 | 0.77 | 0.79 | 98 | empty |
| 4 | 617 | 0.76 | 0.82 | 65 | empty |
| 5 | 333 | 0.55 | 0.75 | 41 | empty |
Interfaces
1 interface between chains.
- A–B · 2212 Ų buried · 41 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 modified (engineered).
Compared structures
- 4JZA · Crystal structure of a Legionella phosphoinositide phosphatase: insights into lipid… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D3HMN4
- Elsewhere: RCSB PDB 4JZA · PDBe 4JZA · UniProt D3HMN4
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