MolNFT v1 · #96629 · protein
The structure of a ternary complex between chea domains P4 and P5 with chew and with an unzipped fragment of TM14, a chemoreceptor analog from thermotoga maritima.
4JPB · Chemotaxis protein chea: “The structure of a ternary complex between chea domains P4 and P5 with chew and with an unzipped fragment of…”. X-ray diffraction, 4 pockets (best druggability 0.52). MolNFT v1 #96629 on GenesisL1: 3D…
- PDB
- 4JPB
- Type
- protein
- Length
- 440 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chemotaxis protein chea; Chemotaxis protein chew; Methyl-accepting chemotaxis protein
- EC
- 2.7.13.3
- UniProt
- Q56310, Q56311, Q7DFA3
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 4 distinct chains · 45% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chemotaxis protein chea (EC 2.7.13.3) | protein | 131 | 11% helix, 56% strand | Q56310 |
| W | Chemotaxis protein chew | protein | 140 | 16% helix, 51% strand | Q56311 |
| B | Methyl-accepting chemotaxis protein | protein | 84 | 95% helix, 0% strand | Q7DFA3 |
| C | Methyl-accepting chemotaxis protein | protein | 85 | 95% helix, 0% strand | Q7DFA3 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 264 | 0.52 | 0.75 | 26 | empty |
| 2 | 105 | 0.39 | 0.75 | 17 | empty |
| 3 | 54 | 0.30 | 0.75 | 15 | empty |
| 4 | 51 | 0.27 | 0.74 | 9 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1882 Ų buried · 11 hydrogen bonds · protein-protein
- A–W · 892 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 483 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4JPB · The structure of a ternary complex between CheA domains P4 and P5 with CheW and with an… · the same entry in another collection · chain A against A, TM-score 1.00
- Q56310 · AlphaFold monomer V2.0 prediction for chemotaxis protein chea (Q56310) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q56311 · AlphaFold monomer V2.0 prediction for chemotaxis protein chew (Q56311) · a predicted model of the same protein · chain W against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q56310
- Every structure of UniProt Q56311
- Every structure of UniProt Q7DFA3
- Elsewhere: RCSB PDB 4JPB · PDBe 4JPB · UniProt Q56310 · UniProt Q56311 · UniProt Q7DFA3
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