UniProt Q56310
Chemotaxis protein CheA (Q56310)
Chemotaxis protein CheA (UniProt Q56310), EC 2.7.13.3: 36 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q56310
- Protein
- Chemotaxis protein CheA
- EC
- 2.7.13.3
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 24 · 7 records with a druggable one
Structures
37 records of Q56310 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B3Q | Crystal structure of chea-289, a signal transducing histidine kinase | x-ray diffraction | A, B | — | — |
| 1B3Q | Crystal structure of chea-289, a signal transducing histidine kinase | x-ray diffraction | A, B | — | — |
| 1I58 | Structure of the histidine kinase chea ATP-binding domain in complex with ATP analog adpcp and… | x-ray diffraction | A, B | — | — |
| 1I58 | Structure of the histidine kinase chea ATP-binding domain in complex with ATP analog adpcp and… | x-ray diffraction | A, B | — | — |
| 1I59 | Structure of the histidine kinase chea ATP-binding domain in complex with adpnp and magensium | x-ray diffraction | A, B | — | — |
| 1I59 | Structure of the histidine kinase chea ATP-binding domain in complex with adpnp and magensium | x-ray diffraction | A, B | — | — |
| 1I5A | Structure of chea domain P4 in complex with adpcp and manganese | x-ray diffraction | A, B | — | — |
| 1I5A | Structure of chea domain P4 in complex with adpcp and manganese | x-ray diffraction | A, B | — | — |
| 1I5B | Structure of chea domain P4 in complex with adpnp and manganese | x-ray diffraction | A, B | — | — |
| 1I5B | Structure of chea domain P4 in complex with adpnp and manganese | x-ray diffraction | A, B | — | — |
| 1I5C | Structure of chea domain P4 in complex with ADP | x-ray diffraction | A, B | — | — |
| 1I5C | Structure of chea domain P4 in complex with ADP | x-ray diffraction | A, B | — | — |
| 1I5D | Structure of chea domain P4 in complex with tnp-ATP | x-ray diffraction | A | — | — |
| 1I5D | Structure of chea domain P4 in complex with tnp-ATP | x-ray diffraction | A | — | — |
| 1TQG | CheA phosphotransferase domain from Thermotoga maritima | x-ray diffraction | A | — | — |
| 1TQG | Chea phosphotransferase domain from thermotoga maritima | x-ray diffraction | A | — | — |
| 1U0S | Chemotaxis kinase CheA P2 domain in complex with response regulator CheY from the thermophile… | x-ray diffraction | A | — | — |
| 1U0S | Chemotaxis kinase chea P2 domain in complex with response regulator chey from the thermophile… | x-ray diffraction | A | — | — |
| 2CH4 | Complex between Bacterial Chemotaxis histidine kinase CheA domains P4 and P5 and receptor-adaptor… | x-ray diffraction | A, B | — | — |
| 2CH4 | Complex between bacterial chemotaxis histidine kinase chea domains P4 and P5 and receptor-adaptor… | x-ray diffraction | A, B | — | — |
| 2LD6 | Solution Structure of Histidine Phosphotransfer Domain of CheA | solution nmr | A | — | — |
| 2LD6 | Solution structure of histidine phosphotransfer domain of chea | solution nmr | A | — | — |
| 3UR1 | The structure of a ternary complex between CheA domains P4 and P5 with CheW and with a truncated… | x-ray diffraction | A | — | — |
| 3UR1 | The structure of a ternary complex between chea domains P4 and P5 with chew and with a truncated… | x-ray diffraction | A | — | — |
| 4JPB | The structure of a ternary complex between CheA domains P4 and P5 with CheW and with an unzipped… | x-ray diffraction | A | — | — |
| 4JPB | The structure of a ternary complex between chea domains P4 and P5 with chew and with an unzipped… | x-ray diffraction | A | — | — |
| 4XIV | Kinase and Dimerization (P3P4) of the Thermotoga maritima CheA kinase | x-ray diffraction | A, B | ACP, ADP | 6 (best 0.64) |
| 4XIV | Kinase and dimerization (P3P4) of the thermotoga maritima chea kinase | x-ray diffraction | A, B | — | — |
| 6MI6 | Structure of chea domain P4 in complex with an ADP analog | x-ray diffraction | A, B, C, D | SO4, JSJ, ADP | — |
| 6MI6 | Structure of chea domain P4 in complex with an ADP analog | x-ray diffraction | A, B, C, D | SO4, JSJ, ADP | — |
| 8OYZ | Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK10 | x-ray diffraction | B, A | WXC | 3 (best 0.65) |
| 8OZ9 | Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-383 | x-ray diffraction | B, A | W6E | 3 (best 0.60) |
| 8P3N | Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK8 | x-ray diffraction | B, A | ADZ | 3 (best 0.61) |
| 8P3R | Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK4 | x-ray diffraction | A, B | WUT | 3 (best 0.65) |
| 8P59 | Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-333 | x-ray diffraction | A, B | WZF | 3 (best 0.59) |
| 8PF2 | Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK16 | x-ray diffraction | B, A | RCO | 3 (best 0.64) |
| Q56310 | AlphaFold monomer V2.0 prediction for chemotaxis protein chea (Q56310) | predicted | A | — | — |
Ligands
- ADP · Adenosine-5'-diphosphate · in 3 records
- JSJ · 5'-O-[(S)-hydroxy{[(s)-hydroxy{[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl) methyl]disulfanyl}phosphoryl]oxy}phosphoryl]adenosine · in 2 records
- SO4 · Sulfate ion · in 2 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
- ADZ · 9-methyl-9H-purin-6-amine · in 1 record
- RCO · Resorcinol · in 1 record
- W6E · 7-(1~{H}-1,2,3-triazol-5-yl)quinazolin-2-amine · in 1 record
- WUT · 9~{H}-purine · in 1 record
- WXC · 2-azanyl-7,8-dihydro-6~{H}-quinazolin-5-one · in 1 record
- WZF · 7-(2-phenylethoxy)quinazolin-2-amine · in 1 record
Experiment against prediction
- 8OZ9 chain B against the predicted model Q56310: TM-score 0.99, RMSD 0.48 Å
- 8P59 chain B against the predicted model Q56310: TM-score 0.99, RMSD 0.50 Å
- 8OYZ chain B against the predicted model Q56310: TM-score 0.99, RMSD 0.53 Å
- 8OYZ chain A against the predicted model Q56310: TM-score 0.99, RMSD 0.57 Å
- 8OZ9 chain A against the predicted model Q56310: TM-score 0.99, RMSD 0.59 Å
- 8P3R chain A against the predicted model Q56310: TM-score 0.99, RMSD 0.59 Å
- 8PF2 chain A against the predicted model Q56310: TM-score 0.99, RMSD 0.60 Å
- 8P3N chain B against the predicted model Q56310: TM-score 0.99, RMSD 0.60 Å
- 8P59 chain A against the predicted model Q56310: TM-score 0.98, RMSD 0.66 Å
- 8P3N chain A against the predicted model Q56310: TM-score 0.98, RMSD 0.79 Å
Elsewhere
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