MolNFT v1 · #96592 · protein

Streptavidin complex with sbp-tag

4JO6: “Streptavidin complex with sbp-tag”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #96592 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4JO6
Type: protein
Length: 531 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Streptavidin; Sbp-tag
UniProt: P22629
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 11% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D	Streptavidin	protein	120	8% helix, 56% strand	P22629
C	Streptavidin	protein	121	5% helix, 55% strand	P22629
Y, Z	Sbp-tag	protein	25	56% helix, 0% strand	—

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	236	0.59	0.80	29	empty
2	197	0.57	0.80	31	empty
3	187	0.55	0.80	32	empty
4	159	0.52	0.79	32	empty

Interfaces

10 interfaces between chains.

A–B · 1637 Å² buried · 31 hydrogen bonds · protein-protein
C–D · 1609 Å² buried · 28 hydrogen bonds · protein-protein
A–Y · 870 Å² buried · 8 hydrogen bonds · protein-protein
B–Z · 863 Å² buried · 10 hydrogen bonds · protein-protein
D–Z · 730 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4JO6 · Streptavidin complex with SBP-Tag · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22629
Elsewhere: RCSB PDB 4JO6 · PDBe 4JO6 · UniProt P22629

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