MolNFT v1 · #96343 · protein
The conformation of a docking site for SH3 domains is pre-selected in the guanine nucleotide exchange factor rlf
4JGW · Ral guanine nucleotide dissociation stimulator-like 2: “The conformation of a docking site for SH3 domains is pre-selected in the guanine nucleotide exchange factor…”. X-ray diffraction, 8 pockets (best druggability 0.54). MolNFT v1…
- PDB
- 4JGW
- Type
- protein
- Length
- 792 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ral guanine nucleotide dissociation stimulator-like 2
- UniProt
- Q61193
- Pockets
- 8 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ral guanine nucleotide dissociation stimulator-like 2 | protein | 396 | 60% helix, 10% strand | Q61193 |
| B | Ral guanine nucleotide dissociation stimulator-like 2 | protein | 396 | 62% helix, 10% strand | Q61193 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.54 | 0.76 | 35 | empty |
| 2 | 112 | 0.47 | 0.79 | 18 | empty |
| 3 | 133 | 0.42 | 0.75 | 22 | empty |
| 4 | 104 | 0.42 | 0.77 | 20 | empty |
| 5 | 60 | 0.36 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 869 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4JGW · The conformation of a docking site for SH3 domains is pre-selected in the Guanine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q61193 · AlphaFold monomer V2.0 prediction for ral guanine nucleotide dissociation stimulator-like… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61193
- Elsewhere: RCSB PDB 4JGW · PDBe 4JGW · UniProt Q61193
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