MolNFT v1 · #96048 · protein

Middle domain of HSC70-interacting protein, crystal form II

4J8D: “Middle domain of HSC70-interacting protein, crystal form II”. X-ray diffraction, 6 pockets (best druggability 0.55). MolNFT v1 #96048 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4J8D
Type: protein
Length: 642 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HSC70-interacting protein
UniProt: P50503
Pockets: 6 · best druggability 0.55

Structure

x-ray diffraction · 4 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	HSC70-interacting protein	protein	161	70% helix, 0% strand	P50503
B	HSC70-interacting protein	protein	159	69% helix, 0% strand	P50503
C	HSC70-interacting protein	protein	160	72% helix, 0% strand	P50503
D	HSC70-interacting protein	protein	162	69% helix, 0% strand	P50503

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	372	0.55	0.74	43	empty
2	185	0.49	0.77	23	empty
3	223	0.49	0.75	24	empty
4	166	0.47	0.76	25	empty
5	213	0.46	0.74	22	empty

Interfaces

3 interfaces between chains.

C–D · 866 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 444 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 11 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4J8D · Middle domain of Hsc70-interacting protein, crystal form II · the same entry in another collection · chain D against D, TM-score 1.00
P50503 · AlphaFold monomer V2.0 prediction for HSC70-interacting protein (P50503) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50503
Elsewhere: RCSB PDB 4J8D · PDBe 4J8D · UniProt P50503

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.