Research workbench
Middle domain of HSC70-interacting protein, crystal form II
Analyse Middle domain of HSC70-interacting protein, crystal form II in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4J8D
- Type
- protein
- Length
- 642 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HSC70-interacting protein
- UniProt
- P50503
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 4 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HSC70-interacting protein | protein | 161 | 70% helix, 0% strand | P50503 |
| B | HSC70-interacting protein | protein | 159 | 69% helix, 0% strand | P50503 |
| C | HSC70-interacting protein | protein | 160 | 72% helix, 0% strand | P50503 |
| D | HSC70-interacting protein | protein | 162 | 69% helix, 0% strand | P50503 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 372 | 0.55 | 0.74 | 43 | empty |
| 2 | 185 | 0.49 | 0.77 | 23 | empty |
| 3 | 223 | 0.49 | 0.75 | 24 | empty |
| 4 | 166 | 0.47 | 0.76 | 25 | empty |
| 5 | 213 | 0.46 | 0.74 | 22 | empty |
Interfaces
3 interfaces between chains.
- C–D · 866 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 444 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50503
- Elsewhere: RCSB PDB 4J8D · PDBe 4J8D · UniProt P50503
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.