MolNFT v1 · #95867 · protein
Crystal structure of the catalytic domain of human PUS1
4J37 · TRNA pseudouridine synthase a, mitochondrial: “Crystal structure of the catalytic domain of human PUS1”. X-ray diffraction, 2 ligands (SO4, CL), 3 pockets (best druggability 0.56). MolNFT v1 #95867 on GenesisL1: 3D structure…
- PDB
- 4J37
- Type
- protein
- Length
- 299 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA pseudouridine synthase a, mitochondrial
- EC
- 5.4.99.12
- UniProt
- Q9Y606
- Ligands
- SO4, CL
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA pseudouridine synthase a, mitochondrial (EC 5.4.99.12) | protein | 299 | 34% helix, 25% strand | Q9Y606 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.56 | 0.81 | 22 | SO4, CL |
| 2 | 51 | 0.40 | 0.82 | 15 | empty |
| 3 | 74 | 0.30 | 0.73 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y606
- Elsewhere: RCSB PDB 4J37 · PDBe 4J37 · UniProt Q9Y606
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