MolNFT v1 · #95828 · protein
Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex
4J23 · Fibroblast growth factor receptor 2: “Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex”. X-ray diffraction, 7 pockets (best druggability 0.69). MolNFT v1 #95828 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4J23
- Type
- protein
- Length
- 332 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 2; Fibroblast growth factor 1
- EC
- 2.7.10.1
- UniProt
- P21802, P05230
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 198 | 2% helix, 25% strand | P21802 |
| B | Fibroblast growth factor 1 | protein | 134 | 0% helix, 33% strand | P05230 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.69 | 0.96 | 20 | empty |
| 2 | 181 | 0.66 | 0.85 | 40 | empty |
| 3 | 183 | 0.56 | 0.80 | 28 | empty |
| 4 | 160 | 0.54 | 0.80 | 30 | empty |
| 5 | 128 | 0.42 | 0.76 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1350 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4J23 · Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.94
- P21802 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 2 (P21802) · a predicted model of the same protein · chain A against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21802
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 4J23 · PDBe 4J23 · UniProt P21802 · UniProt P05230
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