MolNFT v1 · #95788 · protein

Structure of RRP9

4J0X · Ribosomal RNA-processing protein 9: “Structure of RRP9”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #95788 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4J0X
Type: protein
Length: 731 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosomal RNA-processing protein 9
UniProt: Q06506
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosomal RNA-processing protein 9	protein	365	4% helix, 50% strand	Q06506
B	Ribosomal RNA-processing protein 9	protein	366	4% helix, 50% strand	Q06506

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1168	0.78	0.80	75	empty
2	823	0.77	0.81	80	empty
3	337	0.76	0.87	39	empty
4	314	0.74	0.86	41	empty
5	116	0.45	0.78	27	empty

Interfaces

1 interface between chains.

A–B · 1307 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4J0X · Structure of Rrp9 · the same entry in another collection · chain A against A, TM-score 1.00
Q06506 · AlphaFold monomer V2.0 prediction for ribosomal RNA-processing protein 9 (Q06506) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06506
Elsewhere: RCSB PDB 4J0X · PDBe 4J0X · UniProt Q06506

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