MolNFT v1 · #95688 · protein

Crystal structure of maternal embryonic leucine zipper kinase (melk)

4IXP: “Crystal structure of maternal embryonic leucine zipper kinase (melk)”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #95688 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4IXP
Type: protein
Length: 334 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maternal embryonic leucine zipper kinase
EC: 2.7.11.1, 2.7.10.2
UniProt: Q14680
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Maternal embryonic leucine zipper kinase (EC 2.7.11.1, 2.7.10.2)	protein	334	43% helix, 16% strand	Q14680

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	288	0.68	0.83	34	empty
2	284	0.60	0.78	33	empty
3	76	0.52	0.85	22	empty
4	62	0.34	0.77	12	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4IXP · Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) · the same entry in another collection · chain A against A, TM-score 1.00
Q14680 · AlphaFold monomer V2.0 prediction for maternal embryonic leucine zipper kinase (Q14680) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14680
Elsewhere: RCSB PDB 4IXP · PDBe 4IXP · UniProt Q14680

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.