UniProt Q14680
Maternal embryonic leucine zipper kinase (Q14680)
Maternal embryonic leucine zipper kinase (UniProt Q14680), EC 2.7.10.2, 2.7.11.1: 52 experimental structures on GenesisL1, 15 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q14680
- Protein
- Maternal embryonic leucine zipper kinase
- EC
- 2.7.10.2, 2.7.11.1
- Experimental structures
- 52
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 9 · 2 records with a druggable one
Structures
52 records of Q14680 in the MolNFT archive: 52 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BKY | Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex… | x-ray diffraction | A | — | — |
| 4BKY | Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex… | x-ray diffraction | A | — | — |
| 4BKZ | Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex… | x-ray diffraction | A | — | — |
| 4BKZ | Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex… | x-ray diffraction | A | — | — |
| 4BL1 | Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex… | x-ray diffraction | A | — | — |
| 4BL1 | Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex… | x-ray diffraction | A | — | — |
| 4D2P | Structure of MELK in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2P | Structure of melk in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2T | Structure of MELK in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2T | Structure of melk in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2V | Structure of MELK in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2V | Structure of melk in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2W | Structure of MELK in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4D2W | Structure of melk in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4IXP | Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) | x-ray diffraction | A | — | — |
| 4IXP | Crystal structure of maternal embryonic leucine zipper kinase (melk) | x-ray diffraction | A | — | — |
| 4UMP | Structure of MELK in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4UMP | Structure of melk in complex with inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 4UMQ | Structure of MELK in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMQ | Structure of melk in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMR | Structure of MELK in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMR | Structure of melk in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMT | Structure of MELK in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMT | Structure of melk in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMU | Structure of MELK in complex with inhibitors | x-ray diffraction | A | — | — |
| 4UMU | Structure of melk in complex with inhibitors | x-ray diffraction | A | — | — |
| 5IH8 | Melk in complex with nvs-MELK1 | x-ray diffraction | A | — | — |
| 5IH9 | Melk in complex with nvs-MELK8A | x-ray diffraction | A | — | — |
| 5IHA | Melk in complex with nvs-MELK8F | x-ray diffraction | A | — | — |
| 5IHC | MELK in complex with NVS-MELK12B | x-ray diffraction | A | 6BB | — |
| 5IHC | Melk in complex with nvs-MELK12B | x-ray diffraction | A | — | — |
| 5K00 | Melk in complex with nvs-MELK5 | x-ray diffraction | A | — | — |
| 5M5A | Crystal structure of melk in complex with an inhibitor | x-ray diffraction | A | NA, CL, KSA | — |
| 5MAF | Crystal structure of MELK in complex with an inhibitor | x-ray diffraction | A | CL, XIN | — |
| 5MAF | Crystal structure of melk in complex with an inhibitor | x-ray diffraction | A | CL, XIN | — |
| 5MAG | Crystal structure of MELK in complex with an inhibitor | x-ray diffraction | A | 7KC | — |
| 5MAG | Crystal structure of melk in complex with an inhibitor | x-ray diffraction | A | 7KC | — |
| 5MAH | Crystal structure of MELK in complex with an inhibitor | x-ray diffraction | A | 7KD, CL, NA | — |
| 5MAH | Crystal structure of melk in complex with an inhibitor | x-ray diffraction | A | 7KD, CL, NA | — |
| 5MAI | Crystal structure of melk in complex with an inhibitor | x-ray diffraction | A | 5U5 | — |
| 5TVT | Structure of Maternal Embryonic Leucine Zipper Kinase | x-ray diffraction | A | 7LV | 3 (best 0.64) |
| 5TVT | Structure of maternal embryonic leucine zipper kinase | x-ray diffraction | A | 7LV | — |
| 5TWL | Structure of maternal embryonic leucine zipper kinase | x-ray diffraction | A | H91 | — |
| 5TWU | Structure of Maternal Embryonic Leucine Zipper Kinase | x-ray diffraction | A, B | — | 6 (best 0.75) |
| 5TWU | Structure of maternal embryonic leucine zipper kinase | x-ray diffraction | A, B | — | — |
| 5TWY | Structure of maternal embryonic leucine zipper kinase | x-ray diffraction | A, B | 7LY | — |
| 5TWZ | Structure of maternal embryonic leucine zipper kinase | x-ray diffraction | A | 45R | — |
| 5TX3 | Structure of maternal embryonic leucine zipper kinase | x-ray diffraction | A, B | 7MY | — |
| 6GVX | Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin… | x-ray diffraction | A, B | TAK | — |
| 6GVX | Crystal structure of maternal embryonic leucine zipper kinase (melk) in complex with dorsomorphin… | x-ray diffraction | A, B | TAK | — |
| 6VXR | Structure of maternal embryonic leucine zipper kinase bound to LDSM276 | x-ray diffraction | A | F7D | — |
| Q14680 | AlphaFold monomer V2.0 prediction for maternal embryonic leucine zipper kinase (Q14680) | — | — | — |
Ligands
- CL · Chloride ion · in 5 records
- NA · Sodium ion · in 3 records
- 7KC · ~{N}-[(1~{S})-2-(dimethylamino)-1-phenyl-ethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl) amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide · in 2 records
- 7KD · ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl) amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl) pyrimidin-2-yl]amino]benzamide · in 2 records
- 7LV · 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one · in 2 records
- TAK · 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine · in 2 records
- XIN · Methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl) acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate · in 2 records
- 45R · 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4, 5-tetrahydro-1H-3-benzazepinium · in 1 record
- 5U5 · 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide · in 1 record
- 6BB · 4-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]-3-[(piperidin-4-yl)methoxy]pyridine · in 1 record
- 7LY · 2-(benzyloxy)-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide · in 1 record
- 7MY · 7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one · in 1 record
- F7D · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- H91 · 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one · in 1 record
- KSA · K-252A · in 1 record
Elsewhere
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