MolNFT v1 · #95648 · protein
Crystal structure of the conserved hypothetical protein MJ0927 from methanocaldococcus jannaschii (in C2221 form)
4IWG · UPF0135 protein MJ0927: “Crystal structure of the conserved hypothetical protein MJ0927 from methanocaldococcus jannaschii (in C2221…”. X-ray diffraction, 7 pockets (best druggability 0.71). MolNFT v1 #95648 on GenesisL1: 3D…
- PDB
- 4IWG
- Type
- protein
- Length
- 732 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UPF0135 protein MJ0927
- UniProt
- Q58337
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | UPF0135 protein MJ0927 | protein | 244 | 39% helix, 21% strand | Q58337 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 644 | 0.71 | 0.78 | 43 | empty |
| 2 | 211 | 0.53 | 0.78 | 31 | empty |
| 3 | 145 | 0.50 | 0.79 | 28 | empty |
| 4 | 122 | 0.42 | 0.76 | 25 | empty |
| 5 | 122 | 0.41 | 0.75 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–C · 686 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 681 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 678 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4IWG · Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q58337 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 type 2 homolog (Q58337) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58337
- Elsewhere: RCSB PDB 4IWG · PDBe 4IWG · UniProt Q58337
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