MolNFT v1 · #95602 · protein

High resolution crystal structure of racemic ester insulin

4IUZ · Insulin a chain: “High resolution crystal structure of racemic ester insulin”. X-ray diffraction. MolNFT v1 #95602 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4IUZ
Type: protein
Length: 51 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin a chain; Insulin B chain
UniProt: P01308

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin a chain	protein	21	57% helix, 5% strand	P01308
B	Insulin B chain	protein	30	47% helix, 3% strand	P01308

Ligands and binding sites

PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 809 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4IUZ · High resolution crystal structure of racemic ester insulin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 4IUZ · PDBe 4IUZ · UniProt P01308

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