MolNFT v1 · #95238 · protein
High resolution structure of GCAMP3 dimer form 1 at pH 7.5
4IK8 · Rcamp, green fluorescent protein: “High resolution structure of GCAMP3 dimer form 1 at pH 7.5”. X-ray diffraction, 2 ligands (CRO, CA), 5 pockets (best druggability 0.73). MolNFT v1 #95238 on GenesisL1: 3D structure, binding sites…
- PDB
- 4IK8
- Type
- protein
- Length
- 395 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rcamp, green fluorescent protein
- UniProt
- K4DIE3, P42212
- Ligands
- CRO, CA
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rcamp, green fluorescent protein | protein | 395 | 34% helix, 31% strand | K4DIE3, P42212 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 513 | 0.73 | 0.81 | 48 | CRO |
| 2 | 595 | 0.64 | 0.74 | 46 | empty |
| 3 | 115 | 0.46 | 0.79 | 20 | empty |
| 4 | 67 | 0.34 | 0.77 | 21 | empty |
| 5 | 53 | 0.32 | 0.78 | 17 | empty |
Modifications
Observed in the structure: 2 cofactor (chromophore).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K4DIE3
- Every structure of UniProt P42212
- Elsewhere: RCSB PDB 4IK8 · PDBe 4IK8 · UniProt K4DIE3 · UniProt P42212
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.