MolNFT v1 · #95234 · protein

High resolution structure of GCAMP3 at pH 5.0

4IK4 · Rcamp, green fluorescent protein: “High resolution structure of GCAMP3 at pH 5.0”. X-ray diffraction, 2 ligands (CRO, CA), 3 pockets (best druggability 0.72). MolNFT v1 #95234 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4IK4
Type: protein
Length: 395 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rcamp, green fluorescent protein
UniProt: K4DIE3, P42212
Ligands: CRO, CA
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rcamp, green fluorescent protein	protein	395	34% helix, 31% strand	K4DIE3, P42212

Ligands and binding sites

CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
CA · Calcium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	517	0.72	0.81	48	CRO
2	626	0.65	0.74	45	empty
3	63	0.38	0.79	13	empty

Modifications

Observed in the structure: 2 cofactor (chromophore).

Compared structures

4IK4 · High resolution structure of GCaMP3 at pH 5.0 · the same entry in another collection · chain A against A, TM-score 1.00
P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain A against A, TM-score 0.37

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K4DIE3
Every structure of UniProt P42212
Elsewhere: RCSB PDB 4IK4 · PDBe 4IK4 · UniProt K4DIE3 · UniProt P42212

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