MolNFT v1 · #95222 · protein + RNA
Crystal structure of nucleocapsid protein encoded by the prototypic member of orthobunyavirus
4IJS · Nucleoprotein: “Crystal structure of nucleocapsid protein encoded by the prototypic member of orthobunyavirus”. X-ray diffraction, 11 pockets (best druggability 0.83). MolNFT v1 #95222 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4IJS
- Type
- protein + RNA
- Length
- 965 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')
- UniProt
- P16495
- Pockets
- 11 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Nucleoprotein | protein | 232 | 50% helix, 6% strand | P16495 |
| E | RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | rna | 10 | — | — |
| F, G, H | RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | rna | 9 | — | — |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.83 | 0.95 | 39 | empty |
| 2 | 280 | 0.82 | 0.93 | 33 | empty |
| 3 | 226 | 0.81 | 0.94 | 34 | empty |
| 4 | 176 | 0.81 | 0.96 | 36 | empty |
| 5 | 237 | 0.49 | 0.75 | 30 | empty |
Interfaces
7 interfaces between chains.
- D–H · 1473 Ų buried · 19 hydrogen bonds · protein-nucleic
- C–G · 1431 Ų buried · 19 hydrogen bonds · protein-nucleic
- B–F · 1417 Ų buried · 13 hydrogen bonds · protein-nucleic
- A–E · 1377 Ų buried · 16 hydrogen bonds · protein-nucleic
- A–B · 319 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4IJS · Crystal structure of nucleocapsid protein encoded by the prototypic member of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16495
- Elsewhere: RCSB PDB 4IJS · PDBe 4IJS · UniProt P16495
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