MolNFT v1 · #95101 · protein
Crystal structure of the zymogen catalytic region of human masp-1
4IGD · Mannan-binding lectin serine protease 1: “Crystal structure of the zymogen catalytic region of human masp-1”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #95101 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4IGD
- Type
- protein
- Length
- 397 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mannan-binding lectin serine protease 1
- EC
- 3.4.21.-
- UniProt
- P48740
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mannan-binding lectin serine protease 1 (EC 3.4.21.-) | protein | 397 | 8% helix, 37% strand | P48740 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.43 | 0.79 | 23 | empty |
| 2 | 68 | 0.36 | 0.78 | 24 | empty |
| 3 | 69 | 0.32 | 0.75 | 18 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4IGD · Crystal structure of the zymogen catalytic region of Human MASP-1 · the same entry in another collection · chain A against A, TM-score 1.00
- P48740 · AlphaFold monomer V2.0 prediction for mannan-binding lectin serine protease 1 (P48740) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48740
- Elsewhere: RCSB PDB 4IGD · PDBe 4IGD · UniProt P48740
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