UniProt P48740
Mannan-binding lectin serine protease 1 (P48740)
Mannan-binding lectin serine protease 1 (UniProt P48740), EC 3.4.21.-: 15 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 17 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P48740
- Protein
- Mannan-binding lectin serine protease 1
- EC
- 3.4.21.-
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 17 · 1 record with a druggable one
Structures
16 records of P48740 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3GOV | Crystal structure of the catalytic region of human MASP-1 | x-ray diffraction | A, B | — | — |
| 3GOV | Crystal structure of the catalytic region of human masp-1 | x-ray diffraction | A, B | — | — |
| 4AQB | MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44 | x-ray diffraction | A | — | — |
| 4AQB | Mbl-ficolin associated protein-1, MAP-1 aka MAP44 | x-ray diffraction | A | — | — |
| 4DJZ | Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution… | x-ray diffraction | A, B, C, D | — | — |
| 4DJZ | Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution… | x-ray diffraction | A, B, C, D | — | — |
| 4IGD | Crystal structure of the zymogen catalytic region of Human MASP-1 | x-ray diffraction | A | — | — |
| 4IGD | Crystal structure of the zymogen catalytic region of human masp-1 | x-ray diffraction | A | — | — |
| 4IW4 | Crystal structure of the serine protease domain of MASP-3 in complex with ecotin | x-ray diffraction | E, F | — | — |
| 4IW4 | Crystal structure of the serine protease domain of masp-3 in complex with ecotin | x-ray diffraction | E, F | — | — |
| 4KKD | The X-ray crystal structure of Mannose-binding lectin-associated serine proteinase-3 reveals the… | x-ray diffraction | A, B | — | — |
| 4KKD | The X-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the… | x-ray diffraction | A, B | — | — |
| 7ARX | Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1 | x-ray diffraction | A, B | — | 1 (best 0.41) |
| 7ARX | Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1 | x-ray diffraction | A, B | — | — |
| 7PQO | Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin | x-ray diffraction | C, A, B | NA | 16 (best 0.85) |
| P48740 | AlphaFold monomer V2.0 prediction for mannan-binding lectin serine protease 1 (P48740) | predicted | A | — | — |
Ligands
- NA · Sodium ion · in 1 record
Experiment against prediction
- 3GOV chain B against the predicted model P48740: TM-score 0.97, RMSD 1.31 Å
- 3GOV chain B against the predicted model P48740: TM-score 0.97, RMSD 1.31 Å
- 7ARX chain B against the predicted model P48740: TM-score 0.96, RMSD 1.38 Å
- 7ARX chain B against the predicted model P48740: TM-score 0.96, RMSD 1.38 Å
- 4DJZ chain B against the predicted model P48740: TM-score 0.96, RMSD 1.38 Å
- 4DJZ chain B against the predicted model P48740: TM-score 0.96, RMSD 1.38 Å
- 4IGD chain A against the predicted model P48740: TM-score 0.96, RMSD 1.75 Å
- 4IGD chain A against the predicted model P48740: TM-score 0.96, RMSD 1.75 Å
- 4DJZ chain A against the predicted model P48740: TM-score 0.96, RMSD 0.93 Å
- 4DJZ chain A against the predicted model P48740: TM-score 0.96, RMSD 0.93 Å
Elsewhere
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