MolNFT v1 · #94987 · protein

HER2 1221/1222 phosphorylation regulated by PTPN9

4ICZ · Tyrosine-protein phosphatase non-receptor type 9: “HER2 1221/1222 phosphorylation regulated by PTPN9”. X-ray diffraction, 1 pocket (best druggability 0.42). MolNFT v1 #94987 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4ICZ
Type: protein
Length: 297 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 9; HER2
EC: 3.1.3.48
UniProt: P43378
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48)	protein	292	38% helix, 24% strand	P43378
F	HER2	protein	5	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	97	0.42	0.78	16	empty

Interfaces

1 interface between chains.

A–F · 539 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

4ICZ · HER2 1221/1222 phosphorylation regulated by PTPN9 · the same entry in another collection · chain A against A, TM-score 1.00
P43378 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 9… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43378
Elsewhere: RCSB PDB 4ICZ · PDBe 4ICZ · UniProt P43378

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.