MolNFT v1 · #94965 · protein
Crystal structure of the apo ERK5 kinase domain
4IC8 · Mitogen-activated protein kinase 7: “Crystal structure of the apo ERK5 kinase domain”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1 #94965 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4IC8
- Type
- protein
- Length
- 661 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 7
- EC
- 2.7.11.24
- UniProt
- Q13164
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 7 (EC 2.7.11.24) | protein | 325 | 33% helix, 11% strand | Q13164 |
| B | Mitogen-activated protein kinase 7 (EC 2.7.11.24) | protein | 336 | 32% helix, 12% strand | Q13164 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 821 | 0.73 | 0.78 | 77 | empty |
| 2 | 409 | 0.68 | 0.80 | 40 | empty |
| 3 | 128 | 0.61 | 0.85 | 28 | empty |
| 4 | 128 | 0.49 | 0.79 | 27 | empty |
| 5 | 111 | 0.49 | 0.80 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 344 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13164
- Elsewhere: RCSB PDB 4IC8 · PDBe 4IC8 · UniProt Q13164
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