MolNFT v1 · #94614 · protein

Crystal structure of the monomeric (V948R) form of the GEFITINIB/ERLOTINIB resistant EGFR kinase domain L858R+T790M

4I1Z · Epidermal growth factor receptor: “Crystal structure of the monomeric (V948R) form of the GEFITINIB/ERLOTINIB resistant EGFR kinase domain…”. X-ray diffraction, 2 pockets (best druggability 0.64). MolNFT v1 #94614 on GenesisL1: 3D…

PDB: 4I1Z
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epidermal growth factor receptor
EC: 2.7.10.1
UniProt: P00533
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epidermal growth factor receptor (EC 2.7.10.1)	protein	287	38% helix, 19% strand	P00533

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.64	0.82	25	empty
2	352	0.60	0.77	48	empty

Compared structures

4I1Z · Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR… · the same entry in another collection · chain A against A, TM-score 1.00
P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00533
Elsewhere: RCSB PDB 4I1Z · PDBe 4I1Z · UniProt P00533

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