MolNFT v1 · #94163 · protein
Crystal structure of the complex of type 1 ribosome inactivating protein from momordica balsamina with B-D-galactopyranosyl-(1-4)-D- glucose at 2.0 a resolution
4HOA · RRNA N-glycosidase: “Crystal structure of the complex of type 1 ribosome inactivating protein from momordica balsamina with…”. X-ray diffraction, 3 ligands (NAG, BGC, GAL), 2 pockets (best druggability 0.48). MolNFT v1 #94163 on…
- PDB
- 4HOA
- Type
- protein
- Length
- 246 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RRNA N-glycosidase
- EC
- 3.2.2.22
- UniProt
- D9J2T9
- Ligands
- NAG, BGC, GAL
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RRNA N-glycosidase (EC 3.2.2.22) | protein | 246 | 42% helix, 24% strand | D9J2T9 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- BGC · beta-D-glucopyranose · sugar · chains A
- GAL · beta-D-galactopyranose · sugar · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.48 | 0.79 | 21 | GAL |
| 2 | 60 | 0.33 | 0.76 | 13 | empty |
Modifications
Observed in the structure: 1 glycan (N-glycosylation).
Compared structures
- 4HOA · Crystal structure of the complex of type 1 ribosome inactivating protein from Momordica… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D9J2T9
- Elsewhere: RCSB PDB 4HOA · PDBe 4HOA · UniProt D9J2T9
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